GHK-Cu (glycyl-L-histidyl-L-lysine:copper complex) represents one of the most extensively studied peptides in regenerative biology. First isolated from human plasma in 1973, this naturally occurring tripeptide has since been shown to influence thousands of genes involved in tissue repair, inflammation control, and matrix remodeling.

What makes GHK-Cu remarkable is its dual function. As a copper chaperone, it safely delivers copper to enzymes essential for collagen and elastin cross-linking (like lysyl oxidase and SOD1). As a signaling molecule, it triggers pro-repair gene programs — stimulating collagen synthesis, glycosaminoglycan production, and decorin expression while balancing the matrix metalloproteinases (MMPs) that remodel damaged tissue.

Human clinical data supports GHK-Cu’s role in wound healing (including diabetic ulcer studies) and post-procedure recovery (laser resurfacing trials). Preclinical research continues to expand into hair follicle biology, nervous system function, and age-related tissue decline — driven by the observation that plasma GHK-Cu levels drop from approximately 200 ng/mL in young adults to just 80 ng/mL by age 60.

For research teams investigating tissue regeneration, wound healing, or age-related decline, GHK-Cu provides a well-characterized, multi-pathway tool with decades of scientific literature supporting its biological activity.

For research use only. Not for human consumption.